AICAR and compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro

HCC is marked by genetic heterogeneity and activated hepatic stellate cells (HSC) are considered key players during development. The paracrine effect of different cell lines on the activation primary hHSC was accompanied differential AMPK depending line used. Pharmacological treatment inhibited HCC-induced through AMPK-dependent AMPK-independent mechanisms. This heterogenic confirmed data mining TCGA LICA-FR databases.